NAD+

Historical Background

NAD+ is a coenzyme found in all living cells, critical for metabolism and cellular energy. NAD+ precursors (like NMN and NR) have become popular anti-aging supplements based on extensive longevity research showing declining NAD+ with age.

What It's Used For

• Cellular energy production
• DNA repair and longevity
• Mitochondrial function enhancement
• Anti-aging and age reversal
• Metabolism improvement
• Mental clarity and cognition
• Physical endurance and athletic performance
• Circadian rhythm regulation

Positive Effects

• Restores cellular NAD+ levels (critical for aging)
• Enhances mitochondrial function and ATP production
• Activates sirtuins (longevity genes)
• Improves DNA repair mechanisms
• Enhances metabolic flexibility
• Improves cellular energy availability
• Supports cognitive function
• May improve lifespan and healthspan

Potential Side Effects

• Minimal reported side effects
• Possible mild nausea (especially IV forms)
• Flushing (more common with immediate forms)
• Headaches (rare)
• Generally very well-tolerated
• Safe for long-term use

Administration

Available as injectable (IV/IM NAD+), intranasal, or oral precursors (NMN, NR). IV NAD+ most bioavailable: 250-1000mg per session, typically 1-2x weekly. Oral forms dosed 250-1000mg daily. Results accumulate over weeks to months. Part of comprehensive anti-aging protocol.